Andarine (S4) SARMS- What is it?

The Complete Guide to Andarine

Anabolic steroids were pretty much the only option available decades ago when bodybuilders wanted a boost in muscle growth. Unfortunately, the compounds did come with a lot of repercussions which made a lot of people question the value of using them in the first place. Cases of instant death caused by the usage of anabolic steroids were not very rare. Liver toxicity, cardiovascular issues, and shrinking balls were just but a few of the complications resulting from the use of AAS.

Some years later, a new class of performance enhancing drugs took the bodybuilding industry by a storm. The compounds proved to be capable of delivering all the effects bodybuilders desire without the life-threatening and unpleasant side effects that were associated with anabolic steroids. These drugs have come to be known as selective androgen receptor modulators (SARM).

Andarine (S4) is one of the few SARMs available in the market today. This substance is formulated to yield multiple effects that do not just place it as an ideal bodybuilding compound but as a potential medicinal drug as well. Andarine is already under various trials investigating it as a treatment for bone degenerating and muscle wasting disorders.


Andarine was initially under the development of a Japanese pharmaceutical company known as Kaken Pharmaceuticals. The objective behind its creation was to come up with a compound that could help in resolving osteoporosis. Studies showed that the ability of Andarine to bind to the androgen receptors in the muscle and bone tissues helped in boosting bone density thus keeping the users safe from both bone and muscle wasting disorders.

Kaken Pharmaceuticals abandoned the research of the chemical, but that was not before other research companies had already gained some interest in the compound. Its development was hence taken up by other companies, and that’s how the compound is still available in the market today.

In the United States, all selective androgen receptor modulators including Andarine are categorized as investigational new drugs. This essentially means that the compounds are still under trials and hence human consumption is not permitted. Unfortunately, the bodybuilding effects of the substance were just too much to be ignored. This is why fitness enthusiasts across the world continue to use Andarine despite the fact that a lot of information regarding this compound is still unknown.

Benefits of Andarine

As a selective androgen receptor modulator, Andarine binds to the androgen receptors located in your muscle and bone tissues. It will then alter the gene expression here to promote anabolism and protein synthesis which enhances the growth of both bone and muscle tissue. The beauty with Andarine is its exclusivity in dealing with the androgen receptors that are only located in the bone and muscle tissue. That’s because androgen receptors are found in different sites in the body which means that if a compound is not selective on the androgen receptors that it is interacting with, then the risk of side effects increases significantly. That’s precisely why Andarine does not enlarge sex organ as is the case with anabolic androgenic steroids. In fact, trials show that Andarine can actually help in reversing the effect of dihydrotestosterone which included enlarged prostate and head hair loss.

  • Aids in weight loss

Andarine is one of the best fat loss SARMs in the market today. It is actually more androgenic than it is anabolic. S4 will also bind onto the androgen receptors found in adipose tissue. This enhances fat oxidation resulting in the breakdown of fat tissue. In the end, the users will not just see a decrease in body fat but they will also experience increased energy levels since a lot of the fat getting burned is producing energy.

It is crucial to note that all the weight loss effects of Andarine are achieved without affecting the muscle tissues. Therefore, you should never worry about your lean muscle mass being negatively impacted due to taking Andarine.

It is important to remember that Andarine does a great job in breaking down adipose, but it is not a weight loss supplement. The substance will only deliver an excellent fat loss impact if it is used alongside an extensive workout plan and a healthy diet. Even then, the effect won’t be too massive. Therefore, if you are looking for a drastic fat loss, then you are better off looking for an alternative weight loss supplement.

  • Strengthens bone tissue

Kaken Pharmaceuticals was developing a substance that will help in treating osteoporosis when they ended up with Andarine. It, therefore, makes perfect sense that developing healthier bone tissues is one of the many benefits of the substance.

Based on trials done on female rats whose ovaries were removed and castrated male rats, Andarine improved bone mineral density and went a step further to strengthen the muscles.

An improvement in bone density makes Andarine a useful substance in both the medical and fitness sector. As a medicinal compound, S4 can be used by the elderly to deliver healthier bones thus offering protection against frequent injuries and other fractures. In the bodybuilding arena, stronger bones are very crucial if you want to avoid fractures that could keep you off the gym for weeks.

Further research is still required to shed some light on how Andarine can be used for this purpose adequately.

  • Increases muscle mass

Other than treating Osteoporosis, the scientists behind this substance hoped that it could also assist in preventing or reversing muscle wasting. After the development of the compound, animal trials showed that S4 was not just useful in countering muscle wasting, but it also enhanced muscle growth.

In one trial involving castrated rats, S4 increased muscle mass of the rats as remarkably as dihydrotestosterone does. The best part? Andarine achieved this without causing prostate enlargement (the biggest drawback of dihydrotestosterone).

When it comes to gaining muscle mass, Andarine is not the most potent SARM you can get. Perhaps this is because the substance is not as anabolic as most of the other SARMs are. It can, however, be used for slight muscle gains in a cutting cycle where it is more effective.

Side Effects of Andarine

Andarine is safer than anabolic steroids and most of the other SARMs that are highly anabolic. That’s undebatable. Unfortunately, that doesn’t mean that it is entirely safe. Using this substance may still result in some side effects whose severity may vary depending on the doses used, length of cycle and one’s unique reaction to the substance.

With that said, here are some of the commonly reported adverse reactions of Andarine:


The most common and severe side effect linked to Andarine is poor vision. While Andarine is binding to the receptors in the muscles, bones, and adipose, it also tends to attach itself to some of the receptors found in the eyes. This results in a yellow tint that will affect your vision.

Poor vision caused by the consumption of Andarine will make it difficult to see at night and will also slow down your adaptation when moving between rooms that are lit differently.

This effect is dose-dependent. The higher the doses you are consuming the severe the effect. Also, as the doses go higher, the effect will become even more severe, and this is bound to affect your performance and life in general.

It, therefore, goes without saying that new Andarine users should avoid driving at night until they’ve learned of their tolerability to this substance. It’s also important to start with low doses and only increase them if you are reacting well. Reduce the dose immediately you start noticing some changes in your vision.

This issue is usually temporary, and in most cases, you won’t require any special medications to deal with it. As we’ve just said, you can avoid the effect by reducing the dose. If you are experiencing the effect when you are already using low doses, you can stop taking the substance altogether (if it is severe) but if the impact is minimal and you still need the benefits that S4 has to offer, you can run the cycle to the end after which your vision should go back to norm in a couple of days.

In other instances, some people take Andarine for 5 days and then take a break of 2 days before using the substance for another 5 days. This hack has been helpful for people who’ve found the vision issue a bit too much to handle yet they still need the bodybuilding effects of the substance. The problem is that Andarine may not be very useful in delivering any of its positive impacts if it is not used daily. Therefore, you might avoid poor vision issues with this trick, but in the long run, you also won’t have anything to show of it.


Andarine is not the most suppressive SARM in the market, but it will still affect your testosterone production. Since the impact is usually minimal, users can run a mini-PCT to restore normal testosterone levels in no time.

Poor vision and testosterone suppression are the only major side effects reported by Andarine users. This makes them even safer than some of the other more potent SARMs available in the market today. Also, the poor vision issue does not affect everyone. Some people can use high doses of S4 without reporting the yellowish tint that’s affecting other user’s vision.

When you are keen with the doses you are taking, and you run PCT after every cycle, you’ll never have to worry about any complications from using this particular selective androgen receptors modulator.

Andarine Cycle

It is crucial that Andarine is cycled to avoid severe testosterone suppression and vision issues. A typical Andarine cycle usually runs for around 8 weeks. You can also decide to take the SARM for a shorter period like say 6 weeks. Experienced bodybuilders can also stretch the cycles to 10-12 weeks. It all comes down to an individual’s tolerance and the goals they are after. If your tolerability isn’t impressive, you’ll have to stick to shorter cycles, or you might even be forced to end the cycle prematurely. There is really no point in taking a substance that is affecting your normal life. Plus, there are no reasons to suffer unpleasant effects with one compound when there are other SARMs available, right?

If you are using Andarine in a cutting cycle with say Cardarine, you can stack the two SARMs in a cycle of around 8 weeks. This should be enough time to cut on body fat and get the ripped results you need. On the other hand, if you are taking S4 in a phase where you want to cut fat and gain some muscles, you may be forced to stack it with more potent muscle building compounds for a slightly longer period than 8 weeks.

Each cycle of Andarine should be followed by a post cycle therapy phase. The good news is that PCT when using Andarine is usually short since it doesn’t impact testosterone production so much. 4 weeks of HCGenerate ES at 5 tablets per day is usually sufficient to get your testosterone production back to norm. If you had taken Andarine for a slightly longer period of 10 to 12 weeks, you might have to run PCT for 8 weeks.

Andarine Dosage

The recommended dosages of Andarine range from 50 to 75mg per day. S4 has a very short half-life of around 4 hours which means that the dose should be taken twice or even thrice per day. This should keep the compound active in your system long enough to yield maximum benefits.

Now, if you are a newbie, taking more than 50mg per day in your initial doses is nothing short of an extreme sport. This is especially true if you have absolutely no past experience of using SARMs. To be on the safe side, start with low doses of between 25 to 50mg per day taken either twice or three times per day. Continue using that dose for some time while monitoring your response. After one or two weeks of your body getting acclimated to the chemical, you can up the dose gradually over the next few weeks until you reach a point where you are getting the desired effects with no or minimal side effects.

It’s advisable to avoid taking more than 70mg per day regardless of how well you could be responding to S4.

Is it Legal?

Selective androgen receptor modulators fall under a grey area when it comes to legality. These investigational new drugs are not really banned, but they are only supposed to be distributed for research purposes only. It’s due to this complication that the FDA has had a difficult time regulating the substance.

In most countries including the US, Andarine can be purchased online as a research compound. It is also available in the black market for bodybuilders in countries where the laws regulating SARMs are stricter. If you are in such a country and you are still trying to get the drugs, I’ll urge you to be extra careful and make sure that you buy them from a vendor that doesn’t compromise on quality. Low-quality SARMs are extremely dangerous.

What does the law say about SARMs in sports? Well, don’t even think about using Andarine if you are a professional athlete participating in a competitive sport. SARMs are among the drugs prohibited by the World Anti-Doping Agency, the US Anti-Doping Agency and many other sports commissions.

Bodybuilding Uses of Andarine

  1. Cutting

Andarine binds to the androgen receptors found in adipose where it stimulates fat oxidation. This results in a faster breakdown of fat thus enhancing fat loss. In addition to that, S4 will enhance fat loss by reducing the secretion of lipoprotein lipase. This is the enzyme that promotes accumulation of lipids in the body and hence when its production is suppressed, your body will accumulate fewer fats. In essence, Andarine helps with both reducing existing fat and preventing the formation of new fat in the body.

For better cutting results, Andarine can be used with another popular cutting SARM known as Cardarine. Combine around 50mg per day of Andarine with 20mg per day of Cardarine for a period of approximately 10 to 12 weeks to get amazing cutting results with minimal side effects.

  • Increase Strength

Andarine has also proven itself to be incredible in boosting strength and endurance. The reason behind this is really simple. The substance will continually burn the excess fat in the body to produce energy that keeps you fueled.

By binding to the androgen receptors in the muscle tissues, Andarine will also enhance protein synthesis which is vital in keeping your muscles fed and growing. This ensures that you have the extra cutting edge to work out for longer periods before the onset of fatigue. With more strength and endurance, building muscles should become much easier and quicker.

For exceptional strength gains, one should combine Andarine with Ostarine and Cardarine. However, you must make sure that your meals are 30% lean protein.

  • Bulking

Andarine is not the most potent bulking SARM in the market. If you are looking for massive muscle gains, I’d suggest that you check out other more anabolic SARMs such as Testolone, YK11, and Ligandrol. But if you want subtle muscle gain while maintaining a lean physique, you can take Andarine with Testolone (RAD 140). 50 mg/day of Andarine and 10 mg/day of RAD-140 taken for 8 to 12 weeks with a high-calorie diet should deliver reasonable bulking results.

  • Recomping

Andarine can also be stacked alongside other SARMs to burn fat while increasing muscle mass at the same time. In a recomping phase, you can take 50 mg/day of Andarine, 25 mg/day of Ostarine Ostabolic (MK2866) and 20mgs/day of Cardarine (GW501516). Run this cycle for 8-12 weeks while taking a caloric deficit diet.


What makes a lot of people love this SARM is the fact that it delivers the needed results with minimal to no side effects. The substance is even safe from some of the adverse reactions that we associate with most of the other SARMs.

If you are looking for an excellent cutting SARM, then you need to consider Andarine S4 seriously. Stack this SARM with Cardarine, and you can watch yourself lose all the body fat standing between you and that vascularity you desire so much.